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MFG-E8 drives melanoma growth by stimulating mesenchymal stromal cell-induced angiogenesis and M2 polarization of tumor-associated macrophages

Secretion of the powerful angiogenic factor MFG-E8 by pericytes can bypass the therapeutic effects of anti-VEGF therapy, but the mechanisms by which MGF-E8 acts are not fully understood. In this study, we investigated how this factor acts to promote the growth of melanomas which express it. We found...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Yamada, Kazuya, Uchiyama, Akihiko, Uehara, Akihito, Perera, Buddhini, Ogino, Sachiko, Yokoyama, Yoko, Takeuchi, Yuko, Udey, Mark C., Ishikawa, Osamu, Motegi, Sei-ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033700/
https://ncbi.nlm.nih.gov/pubmed/27197197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2812
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