Analysis of coherent and diffuse scattering using a reference phantom

The estimation of many spectral-based, Quantitative Ultrasound parameters assumes that backscattered echo signals are from a stationary, incoherent scattering process. The accuracy of these assumptions in real tissue can limit the diagnostic value of these parameters and the physical insight about t...

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Publicado no:IEEE Trans Ultrason Ferroelectr Freq Control
Main Authors: Rosado-Mendez, Ivan M., Drehfal, Lindsey C., Zagzebski, James A., Hall, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033677/
https://ncbi.nlm.nih.gov/pubmed/27046872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1109/TUFFC.2016.2547341
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spelling pubmed-50336772017-09-01 Analysis of coherent and diffuse scattering using a reference phantom Rosado-Mendez, Ivan M. Drehfal, Lindsey C. Zagzebski, James A. Hall, Timothy J. IEEE Trans Ultrason Ferroelectr Freq Control Article The estimation of many spectral-based, Quantitative Ultrasound parameters assumes that backscattered echo signals are from a stationary, incoherent scattering process. The accuracy of these assumptions in real tissue can limit the diagnostic value of these parameters and the physical insight about tissue microstructure they can convey. This work presents an empirical decision test to determine the presence of significant coherent contributions to echo signals and whether they are caused by low scatterer number densities or the presence of specular reflectors or scatterers with periodic spacing. This is achieved by computing parameters from echo signals that quantify stationary or non-stationary features related to coherent scattering, and then comparing their values to thresholds determined from a reference material providing diffuse scattering. The paper first presents a number of parameters with demonstrated sensitivity to coherent scattering and describes criteria to select those with highest sensitivity using simulated and phantom-based echo data. Results showed that the echo amplitude signal-to-noise ratio and the multitaper generalized spectrum were the parameters with highest sensitivity to coherent scattering with stationary and non-stationary features, respectively. These parameters were incorporated into the reference-based decision test, which successfully identified regions in simulated and tissue-mimicking phantoms with different incoherent and coherent scattering conditions. When scatterers with periodic organization were detected, the combination of stationary and non-stationary analysis permitted the estimation of the mean spacing below and above the resolution limit imposed by the pulse size. Preliminary applications of this algorithm to human cervical tissue ex vivo showed correspondence between regions of B-mode images showing bright reflectors, tissue interfaces, and hypoechoic regions with regions classified as specular reflectors and low scatterer number density. These results encourage further application of the algorithm to more structurally complex phantoms and tissue. 2016-03-25 2016-09 /pmc/articles/PMC5033677/ /pubmed/27046872 http://dx.doi.org/10.1109/TUFFC.2016.2547341 Text en
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
Rosado-Mendez, Ivan M.
Drehfal, Lindsey C.
Zagzebski, James A.
Hall, Timothy J.
Analysis of coherent and diffuse scattering using a reference phantom
description The estimation of many spectral-based, Quantitative Ultrasound parameters assumes that backscattered echo signals are from a stationary, incoherent scattering process. The accuracy of these assumptions in real tissue can limit the diagnostic value of these parameters and the physical insight about tissue microstructure they can convey. This work presents an empirical decision test to determine the presence of significant coherent contributions to echo signals and whether they are caused by low scatterer number densities or the presence of specular reflectors or scatterers with periodic spacing. This is achieved by computing parameters from echo signals that quantify stationary or non-stationary features related to coherent scattering, and then comparing their values to thresholds determined from a reference material providing diffuse scattering. The paper first presents a number of parameters with demonstrated sensitivity to coherent scattering and describes criteria to select those with highest sensitivity using simulated and phantom-based echo data. Results showed that the echo amplitude signal-to-noise ratio and the multitaper generalized spectrum were the parameters with highest sensitivity to coherent scattering with stationary and non-stationary features, respectively. These parameters were incorporated into the reference-based decision test, which successfully identified regions in simulated and tissue-mimicking phantoms with different incoherent and coherent scattering conditions. When scatterers with periodic organization were detected, the combination of stationary and non-stationary analysis permitted the estimation of the mean spacing below and above the resolution limit imposed by the pulse size. Preliminary applications of this algorithm to human cervical tissue ex vivo showed correspondence between regions of B-mode images showing bright reflectors, tissue interfaces, and hypoechoic regions with regions classified as specular reflectors and low scatterer number density. These results encourage further application of the algorithm to more structurally complex phantoms and tissue.
author Rosado-Mendez, Ivan M.
Drehfal, Lindsey C.
Zagzebski, James A.
Hall, Timothy J.
author_facet Rosado-Mendez, Ivan M.
Drehfal, Lindsey C.
Zagzebski, James A.
Hall, Timothy J.
author_sort Rosado-Mendez, Ivan M.
title Analysis of coherent and diffuse scattering using a reference phantom
title_short Analysis of coherent and diffuse scattering using a reference phantom
title_full Analysis of coherent and diffuse scattering using a reference phantom
title_fullStr Analysis of coherent and diffuse scattering using a reference phantom
title_full_unstemmed Analysis of coherent and diffuse scattering using a reference phantom
title_sort analysis of coherent and diffuse scattering using a reference phantom
container_title IEEE Trans Ultrason Ferroelectr Freq Control
publishDate 2016
url https://ncbi.nlm.nih.gov/pmc/articles/PMC5033677/
https://ncbi.nlm.nih.gov/pubmed/27046872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1109/TUFFC.2016.2547341
_version_ 1817246507150082048

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