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N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A
Botulinum neurotoxin serotype A1 (BoNT/A1) is one of the most dangerous potential bioterrorism agents, and exerts its action by invading motoneurons. It is also a licensed drug widely used for medical and cosmetic applications. Here we report a 2.0 Å resolution crystal structure of BoNT/A1 receptor-...
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| Publicado en: | Nat Struct Mol Biol |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5033645/ https://ncbi.nlm.nih.gov/pubmed/27294781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3245 |
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