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CD301b(+) dendritic cells suppress T follicular helper cells and antibody responses to protein antigens

Strong antibody response is considered a hallmark of a successful vaccine. While dendritic cells (DCs) are important for T follicular helper (Tfh) cell priming, how this process is regulated in vivo is unclear. We show here that the depletion of CD301b(+) DCs specifically enhanced the development of...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kumamoto, Yosuke, Hirai, Toshiro, Wong, Patrick W, Kaplan, Daniel H, Iwasaki, Akiko
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033605/
https://ncbi.nlm.nih.gov/pubmed/27657168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.17979
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