Autophagy as a Survival Mechanism for Squamous Cell Carcinoma Cells in Endonuclease G-Mediated Apoptosis

Safingol, L- threo-dihydrosphingosine, induces cell death in human oral squamous cell carcinoma (SCC) cells through an endonuclease G (endoG) -mediated pathway. We herein determined whether safingol induced apoptosis and autophagy in oral SCC cells. Safingol induced apoptotic cell death in oral SCC...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Masui, Atsushi, Hamada, Masakazu, Kameyama, Hiroyasu, Wakabayashi, Ken, Takasu, Ayako, Imai, Tomoaki, Iwai, Soichi, Yura, Yoshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033396/
https://ncbi.nlm.nih.gov/pubmed/27658240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162786
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