Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect novel common variants. We performed a GWAS of the...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Walford, Geoffrey A., Gustafsson, Stefan, Rybin, Denis, Stančáková, Alena, Chen, Han, Liu, Ching-Ti, Hong, Jaeyoung, Jensen, Richard A., Rice, Ken, Morris, Andrew P., Mägi, Reedik, Tönjes, Anke, Prokopenko, Inga, Kleber, Marcus E., Delgado, Graciela, Silbernagel, Günther, Jackson, Anne U., Appel, Emil V., Grarup, Niels, Lewis, Joshua P., Montasser, May E., Landenvall, Claes, Staiger, Harald, Luan, Jian’an, Frayling, Timothy M., Weedon, Michael N., Xie, Weijia, Morcillo, Sonsoles, Martínez-Larrad, María Teresa, Biggs, Mary L., Chen, Yii-Der Ida, Corbaton-Anchuelo, Arturo, Færch, Kristine, Gómez-Zumaquero, Juan Miguel, Goodarzi, Mark O., Kizer, Jorge R., Koistinen, Heikki A., Leong, Aaron, Lind, Lars, Lindgren, Cecilia, Machicao, Fausto, Manning, Alisa K., Martín-Núñez, Gracia María, Rojo-Martínez, Gemma, Rotter, Jerome I., Siscovick, David S., Zmuda, Joseph M., Zhang, Zhongyang, Serrano-Rios, Manuel, Smith, Ulf, Soriguer, Federico, Hansen, Torben, Jørgensen, Torben J., Linnenberg, Allan, Pedersen, Oluf, Walker, Mark, Langenberg, Claudia, Scott, Robert A., Wareham, Nicholas J., Fritsche, Andreas, Häring, Hans-Ulrich, Stefan, Norbert, Groop, Leif, O’Connell, Jeff R., Boehnke, Michael, Bergman, Richard N., Collins, Francis S., Mohlke, Karen L., Tuomilehto, Jaakko, März, Winfried, Kovacs, Peter, Stumvoll, Michael, Psaty, Bruce M., Kuusisto, Johanna, Laakso, Markku, Meigs, James B., Dupuis, Josée, Ingelsson, Erik, Florez, Jose C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2016
Assuntos:
Genetics/Genomes/Proteomics/Metabolomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033262/
https://ncbi.nlm.nih.gov/pubmed/27416945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0199
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