Lack of R-Ras Leads to Increased Vascular Permeability in Ischemic Retinopathy

PURPOSE: The role of R-Ras in retinal angiogenesis and vascular permeability was evaluated in an oxygen-induced retinopathy (OIR) model using R-Ras knockout (KO) mice and in human diabetic neovascular membranes. METHODS: Mice deficient for R-Ras and their wild-type (WT) littermates were subjected to...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Vähätupa, Maria, Prince, Stuart, Vataja, Suvi, Mertimo, Teija, Kataja, Marko, Kinnunen, Kati, Marjomäki, Varpu, Uusitalo, Hannu, Komatsu, Masanobu, Järvinen, Tero A.H., Uusitalo–Järvinen, Hannele
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2016
Assuntos:
Retina
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5032915/
https://ncbi.nlm.nih.gov/pubmed/27654416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.16-19212
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