Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.

Proteolytic cleavage of the protective antigen (PA) protein of anthrax toxin at residues 164-167 is necessary for toxic activity. Cleavage by a cellular protease at this sequence, Arg-Lys-Lys-Arg, normally follows binding of PA to a cell surface receptor. We attempted to identify this protease by de...

Description complète

Détails bibliographiques

Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Klimpel, K R, Molloy, S S, Thomas, G, Leppla, S H
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1992
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50321/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1438214/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.21.10277
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!