Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit(Wv) Mutations

In human-to-mouse xenograft models, reconstitution of human hematopoiesis is usually B-lymphoid dominant. Here we show that the introduction of homozygous Kit(Wv) mutations into C57BL/6.Rag2(null)Il2rg(null) mice with NOD-Sirpa (BRGS) strongly promoted human multi-lineage reconstitution. After xenot...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Yurino, Ayano, Takenaka, Katsuto, Yamauchi, Takuji, Nunomura, Takuya, Uehara, Yasufumi, Jinnouchi, Fumiaki, Miyawaki, Kohta, Kikushige, Yoshikane, Kato, Koji, Miyamoto, Toshihiro, Iwasaki, Hiromi, Kunisaki, Yuya, Akashi, Koichi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031955/
https://ncbi.nlm.nih.gov/pubmed/27499200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.07.002
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