Disrupted brain metabolic connectivity in a 6-OHDA-induced mouse model of Parkinson’s disease examined using persistent homology-based analysis

Movement impairments in Parkinson’s disease (PD) are caused by the degeneration of dopaminergic neurons and the consequent disruption of connectivity in the cortico-striatal-thalamic loop. This study evaluated brain metabolic connectivity in a 6-Hydroxydopamine (6-OHDA)-induced mouse model of PD usi...

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Publicado en:Sci Rep
Main Authors: Im, Hyung-Jun, Hahm, Jarang, Kang, Hyejin, Choi, Hongyoon, Lee, Hyekyoung, Hwang, Do Won, Kim, E. Edmund, Chung, June-Key, Lee, Dong Soo
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030651/
https://ncbi.nlm.nih.gov/pubmed/27650055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33875
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