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Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases
Human DNA2 (hDNA2) contains both a helicase and a nuclease domain within the same polypeptide. The nuclease of hDNA2 is involved in a variety of DNA metabolic processes. Little is known about the role of the hDNA2 helicase. Using bulk and single-molecule approaches, we show that hDNA2 is a processiv...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5030094/ https://ncbi.nlm.nih.gov/pubmed/27612385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18574 |
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