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Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases

Human DNA2 (hDNA2) contains both a helicase and a nuclease domain within the same polypeptide. The nuclease of hDNA2 is involved in a variety of DNA metabolic processes. Little is known about the role of the hDNA2 helicase. Using bulk and single-molecule approaches, we show that hDNA2 is a processiv...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Pinto, Cosimo, Kasaciunaite, Kristina, Seidel, Ralf, Cejka, Petr
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030094/
https://ncbi.nlm.nih.gov/pubmed/27612385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18574
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