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Inflammatory Adipokines Decrease Expression of Two High Molecular Weight Isoforms of Tropomyosin Similar to the Change in Type 2 Diabetic Patients

Cardiovascular disease and cancer are increased in Type 2 diabetes. TPM1 and TPM4 genes encode proteins associated with cardiovascular and neoplastic disease. High (HMW) and low (LMW) molecular weight isoforms from TPM1 and TPM4 are altered in several cancer cells and the 3'UTR of TPM1 mRNA is...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Savill, Stuart A., Leitch, Helen F., Harvey, John N., Thomas, Trevor H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029944/
https://ncbi.nlm.nih.gov/pubmed/27649540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162908
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