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The gp63 Gene Cluster Is Highly Polymorphic in Natural Leishmania (Viannia) braziliensis Populations, but Functional Sites Are Conserved

GP63 or leishmanolysin is the major surface protease of Leishmania spp. involved in parasite virulence and host cell interaction. As such, GP63 is a potential target of eventual vaccines against these protozoa. In the current study we evaluate the polymorphism of gp63 in Leishmania (Viannia) brazili...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Medina, Lilian S., Souza, Bruno Araújo, Queiroz, Adriano, Guimarães, Luiz Henrique, Lima Machado, Paulo Roberto, M Carvalho, Edgar, Wilson, Mary Edythe, Schriefer, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029894/
https://ncbi.nlm.nih.gov/pubmed/27648939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163284
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