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Discovery and characterization of Isofistularin-3, a marine brominated alkaloid, as a new DNA demethylating agent inducing cell cycle arrest and sensitization to TRAIL in cancer cells

We characterized the brominated alkaloid Isofistularin-3 (Iso-3), from the marine sponge Aplysina aerophoba, as a new DNA methyltransferase (DNMT)1 inhibitor. Docking analysis confirmed our in vitro DNMT inhibition data and revealed binding of Iso-3 within the DNA binding site of DNMT1. Subsequent i...

詳細記述

保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Florean, Cristina, Schnekenburger, Michael, Lee, Jin-Young, Kim, Kyung Rok, Mazumder, Aloran, Song, Sungmi, Kim, Jae-Myun, Grandjenette, Cindy, Kim, Jeoung-Gyun, Yoon, Ah-Young, Dicato, Mario, Kim, Kyu-Won, Christov, Christo, Han, Byung-Woo, Proksch, Peter, Diederich, Marc
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029682/
https://ncbi.nlm.nih.gov/pubmed/27006469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8210
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