Activation of TRPV2 and BKCa channels by the LL-37 enantiomers stimulates calcium entry and migration of cancer cells

Expression of the antimicrobial peptide hCAP18/LL-37 is associated to malignancy in various cancer forms, stimulating cell migration and metastasis. We report that LL-37 induces migration of three cancer cell lines by activating the TRPV2 calcium-permeable channel and recruiting it to pseudopodia th...

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Pubblicato in:Oncotarget
Autori principali: Gambade, Audrey, Zreika, Sami, Guéguinou, Maxime, Chourpa, Igor, Fromont, Gaëlle, Bouchet, Ana Maria, Burlaud-Gaillard, Julien, Potier-Cartereau, Marie, Roger, Sébastien, Aucagne, Vincent, Chevalier, Stéphan, Vandier, Christophe, Goupille, Caroline, Weber, Günther
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029663/
https://ncbi.nlm.nih.gov/pubmed/26993604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8122
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