BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death

Inhibition of proapoptotic pathways in synovial fibroblasts is one of the major causes of synovial proliferation and hyperplasia in rheumatic diseases. We have shown previously that NF-κB inhibitor BAY 11-7085, through inactivation of PPAR-γ, induces apoptosis in human synovial fibroblasts. In this...

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Publicado en:Oncotarget
Autores principales: Relic, Biserka, Charlier, Edith, Deroyer, Celine, Malaise, Olivier, Neuville, Sophie, Desoroux, Aline, Gillet, Philippe, de Seny, Dominique, Malaise, Michel G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2016
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029633/
https://ncbi.nlm.nih.gov/pubmed/26993765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8042
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