Methylation in the preinitiation domain suppresses gene transcription by an indirect mechanism.
Although the first observations of the inhibitory effect of methylation on gene activity were made almost a decade ago, the mechanism by which methyl groups affect transcription is still obscure. Here we use engineered promoters methylated in vitro in transient transfections to study the mechanism b...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50289/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1332030/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.21.10119 |
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