Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin.

Charybdotoxin (ChTX), a K+ channel blocker, depolarizes human peripheral T lymphocytes and renders them insensitive to activation by mitogen. We observed four types of K+ channels in human T cells: one voltage-activated, and three Ca(2+)-activated. To discern the mechanism by which ChTX depolarizes...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Leonard, R J, Garcia, M L, Slaughter, R S, Reuben, J P
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1992
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50284/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1279670/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.21.10094
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