Genetic variation in catechol-O-methyltransferase modifies effects of clonidine treatment in chronic fatigue syndrome

Clonidine, an α2-adrenergic receptor agonist, decreases circulating norepinephrine and epinephrine, attenuating sympathetic activity. Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment...

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Publicado en:Pharmacogenomics J
Autores principales: Hall, Kathryn T., Kossowsky, Joe, Oberlander, Tim F., Kaptchuk, Ted J., Saul, J. Philip, Wyller, Vegard Bruun, Fagermoen, Even, Sulheim, Dag, Gjerstad, Johannes, Winger, Anette, Mukamal, Kenneth J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5028250/
https://ncbi.nlm.nih.gov/pubmed/27457818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2016.53
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