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Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice
Congenital diaphragmatic hernia (CDH) is a severe birth defect. Wt1-null mouse embryos develop CDH but the mechanisms regulated by WT1 are unknown. We have generated a murine model with conditional deletion of WT1 in the lateral plate mesoderm, using the G2 enhancer of the Gata4 gene as a driver. 80...
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| Pubblicato in: | eLife |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
eLife Sciences Publications, Ltd
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5028188/ https://ncbi.nlm.nih.gov/pubmed/27642710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.16009 |
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