APOBEC3 proteins can copackage and comutate HIV-1 genomes

Although APOBEC3 cytidine deaminases A3G, A3F, A3D and A3H are packaged into virions and inhibit viral replication by inducing G-to-A hypermutation, it is not known whether they are copackaged and whether they can act additively or synergistically to inhibit HIV-1 replication. Here, we showed that A...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Desimmie, Belete A., Burdick, Ryan C., Izumi, Taisuke, Doi, Hibiki, Shao, Wei, Alvord, W. Gregory, Sato, Kei, Koyanagi, Yoshio, Jones, Sara, Wilson, Eleanor, Hill, Shawn, Maldarelli, Frank, Hu, Wei-Shau, Pathak, Vinay K.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027510/
https://ncbi.nlm.nih.gov/pubmed/27439715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw653
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