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Length heterogeneity at conserved sequence block 2 in human mitochondrial DNA acts as a rheostat for RNA polymerase POLRMT activity

The guanine (G)-tract of conserved sequence block 2 (CSB 2) in human mitochondrial DNA can result in transcription termination due to formation of a hybrid G-quadruplex between the nascent RNA and the nontemplate DNA strand. This structure can then influence genome replication, stability and localiz...

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Publicat a:Nucleic Acids Res
Autors principals: Tan, Benedict G., Wellesley, Frederick C., Savery, Nigel J., Szczelkun, Mark D.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027508/
https://ncbi.nlm.nih.gov/pubmed/27436287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw648
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