Synergistic activation of Arg1 gene by retinoic acid and IL-4 involves chromatin remodeling for transcription initiation and elongation coupling

All-trans Retinoic acid (RA) and its derivatives are potent therapeutics for immunological functions including wound repair. However, the molecular mechanism of RA modulation in innate immunity is poorly understood, especially in macrophages. We found that topical application of RA significantly imp...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Lee, Bomi, Wu, Cheng-Ying, Lin, Yi-Wei, Park, Sung Wook, Wei, Li-Na
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Gene regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5027474/
https://ncbi.nlm.nih.gov/pubmed/27166374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw392
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