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Inclusion of epitopes that expand high avidity CD4(+) T cells transforms sub-protective vaccines to efficacious immunogens against virulent Francisella tularensis
T cells are the immunological cornerstone in host defense against infections by intracellular bacterial pathogens, such as virulent Francisella tularensis (Ftt). The general paucity of novel vaccines for Ftt over the past 60 years can, in part, be attributed to the poor understanding of immune param...
Gardado en:
| Publicado en: | J Immunol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5026927/ https://ncbi.nlm.nih.gov/pubmed/27543611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1600879 |
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