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The HCMV US28 vGPCR induces potent Gαq/PLC-β signaling in monocytes leading to increased adhesion to endothelial cells

US28 transcripts have been detected in primary monocytes and in THP-1 monocytes infected with HCMV but US28 protein expression has not yet been demonstrated in these cell types. Moreover, the mechanism(s) by which US28 signals and contributes to viral pathogenesis in monocytes remains unclear. Here,...

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Bibliografski detalji
Izdano u:Virology
Glavni autori: Wu, Shu-en, Miller, William E.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026607/
https://ncbi.nlm.nih.gov/pubmed/27497185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.07.025
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