Endoplasmic Reticulum Stress Links Oxidative Stress to Impaired Pancreatic Beta-Cell Function Caused by Human Oxidized LDL

Elevated plasma concentration of the pro-atherogenic oxidized low density lipoprotein cholesterol (LDL) triggers adverse effects in pancreatic beta-cells and is associated with type 2 diabetes. Here, we investigated whether the endoplasmic reticulum (ER) stress is a key player coupling oxidative str...

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Publicat a:PLoS One
Autors principals: Plaisance, Valérie, Brajkovic, Saška, Tenenbaum, Mathie, Favre, Dimitri, Ezanno, Hélène, Bonnefond, Amélie, Bonner, Caroline, Gmyr, Valéry, Kerr-Conte, Julie, Gauthier, Benoit R., Widmann, Christian, Waeber, Gérard, Pattou, François, Froguel, Philippe, Abderrahmani, Amar
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026355/
https://ncbi.nlm.nih.gov/pubmed/27636901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0163046
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