Mutational analysis of the Aspergillus ambient pH receptor PalH underscores its potential as a target for antifungal compounds

The pal/RIM ambient pH signalling pathway is crucial for the ability of pathogenic fungi to infect hosts. The Aspergillus nidulans 7‐TMD receptor PalH senses alkaline pH, subsequently facilitating ubiquitination of the arrestin PalF. Ubiquitinated PalF triggers downstream signalling events. The mech...

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Detalles Bibliográficos
Publicado en:Mol Microbiol
Main Authors: Lucena‐Agell, Daniel, Hervás‐Aguilar, América, Múnera‐Huertas, Tatiana, Pougovkina, Olga, Rudnicka, Joanna, Galindo, Antonio, Tilburn, Joan, Arst, Herbert N., Peñalva, Miguel A.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026065/
https://ncbi.nlm.nih.gov/pubmed/27279148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13438
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