Mutational analysis of the Aspergillus ambient pH receptor PalH underscores its potential as a target for antifungal compounds

The pal/RIM ambient pH signalling pathway is crucial for the ability of pathogenic fungi to infect hosts. The Aspergillus nidulans 7‐TMD receptor PalH senses alkaline pH, subsequently facilitating ubiquitination of the arrestin PalF. Ubiquitinated PalF triggers downstream signalling events. The mech...

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Detalhes bibliográficos
Publicado no:Mol Microbiol
Main Authors: Lucena‐Agell, Daniel, Hervás‐Aguilar, América, Múnera‐Huertas, Tatiana, Pougovkina, Olga, Rudnicka, Joanna, Galindo, Antonio, Tilburn, Joan, Arst, Herbert N., Peñalva, Miguel A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026065/
https://ncbi.nlm.nih.gov/pubmed/27279148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.13438
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