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ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination
We generate a mouse model for the human microcephaly syndrome by mutating the ASPM locus, and demonstrate a premature exhaustion of the neuronal progenitor pool due to dysfunctional self-renewal processes. Earlier studies have linked ASPM mutant progenitor excessive cell cycle exit to a mitotic orie...
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| Vydáno v: | Nat Commun |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5025044/ https://ncbi.nlm.nih.gov/pubmed/26581405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9763 |
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