Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction

To-date, there has been no effective chiral capillary electrophoresis-mass spectrometry (CE-MS) method reported for the simultaneous enantioseparation of the antidepressant drug, venlafaxine (VX) and its structurally-similar major metabolite, O-desmethylvenlafaxine (O-DVX). This is mainly due to the...

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Publicado en:J Chromatogr A
Main Authors: Liu, Yijin, Jann, Michael, Vandenberg, Chad, Eap, Chin B., A.Shamsi, Shahab
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5025041/
https://ncbi.nlm.nih.gov/pubmed/26460073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chroma.2015.09.088
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