Cytosolic and Calcium-Independent Phospholipases A(2) Activation and Prostaglandins E(2) Are Associated with Escherichia coli-Induced Reduction of Insulin Secretion in INS-1E Cells

It is suspected that microbial infections take part in the pathogenesis of diabetes mellitus type 1 (T1DM). Glucose-induced insulin secretion is accompanied by the release of free arachidonic acid (AA) mainly by cytosolic- and calcium independent phospholipases A(2) (cPLA(2) and iPLA(2)). Insulinoma...

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發表在:PLoS One
Main Authors: Caporarello, Nunzia, Salmeri, Mario, Scalia, Marina, Motta, Carla, Parrino, Cristina, Frittitta, Lucia, Olivieri, Melania, Cristaldi, Martina, Avola, Roberto, Bramanti, Vincenzo, Toscano, Maria Antonietta, Anfuso, Carmelina Daniela, Lupo, Gabriella
格式: Artigo
語言:Inglês
出版: Public Library of Science 2016
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024995/
https://ncbi.nlm.nih.gov/pubmed/27631977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0159874
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