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Glimpse of natural selection of long-lived T-cell clones in healthy life

Homeostatic maintenance of T cells with broad clonal diversity is influenced by both continuing output of young T cells from the thymus and ongoing turnover of preexisting clones in the periphery. In the absence of infection, self and commensal antigens are thought to play important roles in selecti...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Zhang, Baojun, Jia, Qingzhu, Bock, Cheryl, Chen, Gang, Yu, Haili, Ni, Qingshan, Wan, Ying, Li, Qijing, Zhuang, Yuan
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024599/
https://ncbi.nlm.nih.gov/pubmed/27535935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1601634113
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