Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival

The protein kinase maternal and embryonic leucine zipper kinase (MELK) is critical for mitotic progression of cancer cells; however, its mechanisms of action remain largely unknown. By combined approaches of immunoprecipitation/mass spectrometry and peptide library profiling, we identified the eukar...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Wang, Yubao, Begley, Michael, Li, Qing, Huang, Hai-Tsang, Lako, Ana, Eck, Michael J., Gray, Nathanael S., Mitchison, Timothy J., Cantley, Lewis C., Zhao, Jean J.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2016
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024598/
https://ncbi.nlm.nih.gov/pubmed/27528663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606862113
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