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Clathrin light chains’ role in selective endocytosis influences antibody isotype switching

Clathrin, a cytosolic protein composed of heavy and light chain subunits, assembles into a vesicle coat, controlling receptor-mediated endocytosis. To establish clathrin light chain (CLC) function in vivo, we engineered mice lacking CLCa, the major CLC isoform in B lymphocytes, generating animals wi...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wu, Shuang, Majeed, Sophia R., Evans, Timothy M., Camus, Marine D., Wong, Nicole M. L., Schollmeier, Yvette, Park, Minjong, Muppidi, Jagan R., Reboldi, Andrea, Parham, Peter, Cyster, Jason G., Brodsky, Frances M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024586/
https://ncbi.nlm.nih.gov/pubmed/27540116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611189113
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