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A Fluorogenic Screening Platform Enables Directed Evolution of an Alkyne Biosynthetic Tool

Directed evolution was used to improve the activity of JamB, a membrane-bound bifunctional desaturase/acetylenase. To quickly assess the protein engineering outcomes, we developed a new platform for quantifying extracellular alkyne-tagged metabolites through a fluorogenic click reaction. Random muta...

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Détails bibliographiques
Publié dans:Chem Commun (Camb)
Auteurs principaux: Zhu, Xuejun, Shieh, Peyton, Su, Michael, Bertozzi, Carolyn R., Zhang, Wenjun
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023497/
https://ncbi.nlm.nih.gov/pubmed/27561030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc05990b
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