Intratumoral Infection with Murine Cytomegalovirus Synergizes with PD-L1 Blockade to Clear Melanoma Lesions and Induce Long-term Immunity

Cytomegalovirus is an attractive cancer vaccine platform because it induces strong, functional CD8(+) T-cell responses that accumulate over time and migrate into most tissues. To explore this, we used murine cytomegalovirus expressing a modified gp100 melanoma antigen. Therapeutic vaccination by the...

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Vydáno v:Mol Ther
Hlavní autoři: Erkes, Dan A, Xu, Guangwu, Daskalakis, Constantine, Zurbach, Katherine A, Wilski, Nicole A, Moghbeli, Toktam, Hill, Ann B, Snyder, Christopher M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023369/
https://ncbi.nlm.nih.gov/pubmed/27434584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.121
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