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Understanding Heterogeneity in Clinical Cohorts Using Normative Models: Beyond Case-Control Studies
BACKGROUND: Despite many successes, the case-control approach is problematic in biomedical science. It introduces an artificial symmetry whereby all clinical groups (e.g., patients and control subjects) are assumed to be well defined, when biologically they are often highly heterogeneous. By definit...
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| Publicado no: | Biol Psychiatry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5023321/ https://ncbi.nlm.nih.gov/pubmed/26927419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2015.12.023 |
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