Targeted Next-Generation Sequencing of Plasma DNA from Cancer Patients: Factors Influencing Consistency with Tumour DNA and Prospective Investigation of Its Utility for Diagnosis

Use of circulating tumour DNA (ctDNA) as a liquid biopsy has been proposed for potential identification and monitoring of solid tumours. We investigate a next-generation sequencing approach for mutation detection in ctDNA in two related studies using a targeted panel. The first study was retrospecti...

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Foilsithe in:PLoS One
Main Authors: Kaisaki, Pamela J., Cutts, Anthony, Popitsch, Niko, Camps, Carme, Pentony, Melissa M., Wilson, Gareth, Page, Suzanne, Kaur, Kulvinder, Vavoulis, Dimitris, Henderson, Shirley, Gupta, Avinash, Middleton, Mark R., Karydis, Ioannis, Talbot, Denis C., Schuh, Anna, Taylor, Jenny C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023174/
https://ncbi.nlm.nih.gov/pubmed/27626278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162809
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