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Wdr1-Dependent Actin Reorganization in Platelet Activation

In resting platelets, the integrin αIIbβ3 is present in a low-affinity “bent” state. During platelet aggregation, intracytoplasmic signals induce conformational changes (inside-out signaling) that result in a “swung-out” conformation competent to bind ligands such as fibrinogen. The cytoskeleton pla...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Dasgupta, Swapan K., Le, Anhquyen, Da, Qi, Cruz, Miguel, Rumbaut, Rolando E., Thiagarajan, Perumal
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023164/
https://ncbi.nlm.nih.gov/pubmed/27627652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162897
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