Reversion of Cold-Adapted Live Attenuated Influenza Vaccine into a Pathogenic Virus

The only licensed live attenuated influenza A virus vaccines (LAIVs) in the United States (FluMist) are created using internal protein-coding gene segments from the cold-adapted temperature-sensitive master donor virus A/Ann Arbor/6/1960 and HA/NA gene segments from circulating viruses. During seria...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Zhou, Bin, Meliopoulos, Victoria A., Wang, Wei, Lin, Xudong, Stucker, Karla M., Halpin, Rebecca A., Stockwell, Timothy B., Schultz-Cherry, Stacey, Wentworth, David E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021423/
https://ncbi.nlm.nih.gov/pubmed/27440882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00163-16
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