Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation

Munc18-1 is a key component of the exocytic machinery that controls neurotransmitter release. Munc18-1 heterozygous mutations cause developmental defects and epileptic phenotypes, including infantile epileptic encephalopathy (EIEE), suggestive of a gain of pathological function. Here, we used single...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Chai, Ye Jin, Sierecki, Emma, Tomatis, Vanesa M., Gormal, Rachel S., Giles, Nichole, Morrow, Isabel C., Xia, Di, Götz, Jürgen, Parton, Robert G., Collins, Brett M., Gambin, Yann, Meunier, Frédéric A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5021092/
https://ncbi.nlm.nih.gov/pubmed/27597756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201512016
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