EPOXYEICOSATRIENOIC ACID ANALOG MITIGATES KIDNEY INJURY IN A RAT MODEL OF RADIATION NEPHROPATHY

Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by CYP-epoxygenases, and EETs are kidney protective in multiple pathologies. We determined the ability of an EET analog, EET-A, to mitigate experimental radiation nephropathy. The kidney expression of the EET producing enzyme CYP2C1...

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Pubblicato in:Clin Sci (Lond)
Autori principali: Khan, Abdul Hye, Fish, Brian, Wahl, Geneva, Sharma, Amit, Falck, John R., Paudyal, Mahesh P., Moulder, John E., Imig, John D., Cohen, Eric P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020909/
https://ncbi.nlm.nih.gov/pubmed/26772189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20150778
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