Activation of NQO1 in NQO1*2 polymorphic human leukemic HL-60 cells by diet-derived sulforaphane

BACKGROUND: The NAD(P)H: quinone oxidoreductase (NQO1) confers protection against semiquinones and also elicits oxidative stress. The C609T polymorphism of the NQO1 gene, designated NQO1*2, significantly reduces its enzymatic activity due to rapid degradation of protein. Since down regulation of NQO...

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Veröffentlicht in:Exp Hematol Oncol
Hauptverfasser: Wu, Joseph M., Oraee, Ardalan, Doonan, Barbara B., Pinto, John T., Hsieh, Tze-chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020469/
https://ncbi.nlm.nih.gov/pubmed/27625902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40164-016-0056-z
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