The mutated tegument protein UL7 attenuates the virulence of herpes simplex virus 1 by reducing the modulation of α-4 gene transcription

BACKGROUND: UL7, a tegument protein of Herpes Simplex Virus type I (HSV-1), is highly conserved in viral infection and proliferation and has an unknown mechanism of action. METHODS: A HSV-1 UL7 mutant (UL7-MU) was constructed using the CRISPR-cas9 system. The replication rate and plaque morphology w...

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Detalhes bibliográficos
Publicado no:Virol J
Main Authors: Xu, Xingli, Fan, Shengtao, Zhou, Jienan, Zhang, Ying, Che, Yanchun, Cai, Hongzhi, Wang, Lichun, Guo, Lei, Liu, Longding, Li, Qihan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020468/
https://ncbi.nlm.nih.gov/pubmed/27618986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-016-0600-9
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