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Molecular organization, localization and orientation of antifungal antibiotic amphotericin B in a single lipid bilayer

Amphotericin B is a popular antifungal antibiotic, a gold standard in treatment of systemic mycotic infections, due to its high effectiveness. On the other hand, applicability of the drug is limited by its considerable toxicity to patients. Biomembranes are a primary target of physiological activity...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Grudzinski, Wojciech, Sagan, Joanna, Welc, Renata, Luchowski, Rafal, Gruszecki, Wieslaw I.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020354/
https://ncbi.nlm.nih.gov/pubmed/27620838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep32780
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