Preventing Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome in High-Risk Patients: Protocol of a Randomized Placebo-Controlled Trial of Prednisone (PredART Trial)

BACKGROUND: Early antiretroviral therapy (ART) initiation in patients diagnosed with HIV-associated tuberculosis (TB) reduces mortality among those with the lowest CD4 counts. At the same time, both early ART and a low CD4 count heighten the risk of paradoxical TB-associated immune reconstitution in...

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Udgivet i:JMIR Res Protoc
Main Authors: Stek, Cari, Schutz, Charlotte, Blumenthal, Lisette, Thienemann, Friedrich, Buyze, Jozefien, Nöstlinger, Christiana, Ravinetto, Raffaella, Wouters, Edwin, Colebunders, Robert, Maartens, Gary, Wilkinson, Robert J, Lynen, Lutgarde, Meintjes, Graeme
Format: Artigo
Sprog:Inglês
Udgivet: JMIR Publications 2016
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Protocol
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5020311/
https://ncbi.nlm.nih.gov/pubmed/27571786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2196/resprot.6046
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