Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level

G protein–coupled receptors (GPCRs), including dopamine receptors, represent a group of important pharmacological targets. An increased formation of dopamine receptor D(2) homodimers has been suggested to be associated with the pathophysiology of schizophrenia. Selective labeling and ligand-induced...

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Udgivet i:Sci Rep
Main Authors: Tabor, Alina, Weisenburger, Siegfried, Banerjee, Ashutosh, Purkayastha, Nirupam, Kaindl, Jonas M., Hübner, Harald, Wei, Luxi, Grömer, Teja W., Kornhuber, Johannes, Tschammer, Nuska, Birdsall, Nigel J. M., Mashanov, Gregory I., Sandoghdar, Vahid, Gmeiner, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018964/
https://ncbi.nlm.nih.gov/pubmed/27615810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33233
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