Age‐dependent effects of APOE ε4 in preclinical Alzheimer's disease

OBJECTIVE: The ε4 allele of apolipoprotein E (APOE) is the strongest known common genetic risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here, we longitudinally test the effects of APOE ε4 genotype and age during progression from normal cognition to A...

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Udgivet i:Ann Clin Transl Neurol
Main Authors: Bonham, Luke W., Geier, Ethan G., Fan, Chun C., Leong, Josiah K., Besser, Lilah, Kukull, Walter A., Kornak, John, Andreassen, Ole A., Schellenberg, Gerard D., Rosen, Howard J., Dillon, William P., Hess, Christopher P., Miller, Bruce L., Dale, Anders M., Desikan, Rahul S., Yokoyama, Jennifer S.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018579/
https://ncbi.nlm.nih.gov/pubmed/27648456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.333
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