Age‐dependent effects of APOE ε4 in preclinical Alzheimer's disease

OBJECTIVE: The ε4 allele of apolipoprotein E (APOE) is the strongest known common genetic risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here, we longitudinally test the effects of APOE ε4 genotype and age during progression from normal cognition to A...

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: Bonham, Luke W., Geier, Ethan G., Fan, Chun C., Leong, Josiah K., Besser, Lilah, Kukull, Walter A., Kornak, John, Andreassen, Ole A., Schellenberg, Gerard D., Rosen, Howard J., Dillon, William P., Hess, Christopher P., Miller, Bruce L., Dale, Anders M., Desikan, Rahul S., Yokoyama, Jennifer S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018579/
https://ncbi.nlm.nih.gov/pubmed/27648456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.333
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