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Confidence intervals for the selected population in randomized trials that adapt the population enrolled

It is a challenge to design randomized trials when it is suspected that a treatment may benefit only certain subsets of the target population. In such situations, trial designs have been proposed that modify the population enrolled based on an interim analysis, in a preplanned manner. For example, i...

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Detalles Bibliográficos
Publicado en:Biom J
Autor Principal: Rosenblum, Michael
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018400/
https://ncbi.nlm.nih.gov/pubmed/23553577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bimj.201200080
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