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Sustained α-catenin Activation at E-cadherin Junctions in the Absence of Mechanical Force

Mechanotransduction at E-cadherin junctions has been postulated to be mediated in part by a force-dependent conformational activation of α-catenin. Activation of α-catenin allows it to interact with vinculin in addition to F-actin, resulting in a strengthening of junctions. Here, using E-cadherin ad...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Biswas, Kabir H., Hartman, Kevin L., Zaidel-Bar, Ronen, Groves, Jay T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5018127/
https://ncbi.nlm.nih.gov/pubmed/27602732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.06.027
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