Chargement en cours...
A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration
We previously reported that hypoxia-inducible factor (HIF)-1 inhibitor LW6, an aryloxyacetylamino benzoic acid derivative, inhibits malate dehydrogenase 2 (MDH2) activity during the mitochondrial tricarboxylic acid (TCA) cycle. In this study, we present a novel MDH2 inhibitor compound 7 containing b...
Enregistré dans:
Publié dans: | PLoS One |
---|---|
Auteurs principaux: | , , , , , , |
Format: | Artigo |
Langue: | Inglês |
Publié: |
Public Library of Science
2016
|
Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5017629/ https://ncbi.nlm.nih.gov/pubmed/27611801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0162568 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|